Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1992-08-31
1998-02-17
Caputa, Anthony C.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
436544, 436545, 436546, 435 71, 530324, 530325, 530326, 530327, 530328, 530329, G01N 33543, C07K 14195, C07K 1474
Patent
active
057190640
ABSTRACT:
It has been determined that HLA B27 is related to proteins of the Gram negative enteric bacteria. The hypervariable regions of the HLA B alleles were compared to the known sequenced proteins for short consecutive amino acid identities. It was found that, unique to the HLA B alleles,, HLA B27 shares an unexpected number of hexapeptides and pentapeptides with Gram negative bacteria proteins. The proteins from enteric organisms that share sequence with B27 tend to have sequences that satisfy protein sequence motifs which are thought to predict binding to B27. In addition, there is a sequence in B27, LRRYLENGK, which is predicted to bind as a peptide to B27. Binding of this peptide to B27 has been demonstrated. The disclosed peptides are useful for diagnostic and therapeutic purposes and can be used to design additional peptides from Gram negative enteric organisms can be identified to be important in the spondyloarthropathies. These peptides and their analogs can be used to screen for antibodies, and more importantly, T cells reactive with the peptides, which are indicative of the spondyloarthropathies.
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Harley John B.
Scofield R. Hal
Caputa Anthony C.
Oklahoma Medical Research Foundation
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