Chemistry: analytical and immunological testing – Including sample preparation
Patent
1995-06-07
1998-02-17
Alexander, Lyle A.
Chemistry: analytical and immunological testing
Including sample preparation
436173, 436 63, 436178, 250287, 250288, G01N 33537
Patent
active
057190607
ABSTRACT:
This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates to the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.
REFERENCES:
patent: 4295046 (1981-10-01), Gruter et al.
patent: 4686366 (1987-08-01), Stuke
patent: 4694167 (1987-09-01), Payne et al.
patent: 4988879 (1991-01-01), Zare et al.
patent: 5045694 (1991-09-01), Beavis et al.
patent: 5124267 (1992-06-01), Humpel et al.
patent: 5209919 (1993-05-01), Turteltaub et al.
patent: 5547835 (1996-08-01), Koster
Hutchens and Allen; Differences in the Confrontational State of a Zinc-finger DNA-binding Protein Domain Occupied by Zinc and Copper Revealed by Electrospray Ionization Mass Spectrometry; Rap. Comm. in Mass Spec., vol. 6, 469-473, 1992.
Hutchens and Yip; New Desorption Strategies for the Mass Spectrometric Analysis of Macromolecules; Rap. Comm. in Mass Spec.; vol. 7, 576-580, 1993.
Hillenkamp, F.; Laser Desorption Mass Spectrometry: Mechanisms, Techniques and Applications; Advances in Mass Spectrometry; Proc. 11th Int.. Mass. Spec. Conf.; vol. 11A, 354-362, 1988.
Karas and Hillenkamp; Ultraviolet Laser Desorption of Proteins up to 120 000 Daltons; Advances in Mass Spectrometry; Proc. 11th Intl. Mass. Spec. Conf.; vol. 11A, 416-417, 1988.
Hutchens T. William
Yip Tai-Tung
Alexander Lyle A.
Baylor College of Medicine
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