Surgery – Miscellaneous – Methods
Patent
1995-03-24
1996-07-16
Sykes, Angela D.
Surgery
Miscellaneous
Methods
A61B 1900
Patent
active
055357601
ABSTRACT:
The subject matter of this disclosure links Alzheimer's Disease with somatic mosaicism of cells trisomic for chromosome 21. Disclosed are methods of detecting Alzheimer's Disease in an individual by measuring certain characteristics known to be associated with Down syndrome that arise due to the trisomy nature of that disorder.
REFERENCES:
B. Katz, et al., "Cholinergic Supersensitivity of the Iris Sphincter in Alzheimer's Disease," Ophthal., 95:134 (Sep. 1988 Supp).
Sitaram, N. and Pomara, N., "Increased Pupillary Miotic Response to Pilocarpine in Cognitively Impaired Elderly Subjects," ICRS Medical Science, 9:409-410 (1981).
Potter, H., "Review and Hypothesis: Alzheimer Disease and Down Syndrome-Chromosome 21 Nondisjunction May Underlie Both Disorders," Am. J. Hum. Genet., 48:1192-1200 (1991).
Inzelberg, R., et al., "Effects of Atropine on Learning and Memory Functions in Dementia," Clinical Neuropharmacology, 13(3):241-247 (1990).
Schweber, M. S., "Alzheimer's Disease and Down Syndrome," Progress in Clinical and Biol. Research, 317:247-267 (Alan R. Liss, Inc., 1989).
Lichter, P., et al., "Rapid Detection of Human Chromosome 21 Aberrations by in situ Hybridization," Proc. Natl. Acad. Sci. USA, 85:9664-9668 (1988).
Talamo, B. R., et al., "Pathological Changes in Olfactory Neurons in Patients with Alzheimer's Disease," Nature, 337:736-739 (1989).
Schweber, M., "A Possible Unitary Genetic Hypothesis for Alzheimer's Disease and Down Syndrome," Anals of NY Acad. Sciences, 450:223-238 (1985).
Madan, K. et al., "Premature Centromere Division (PCD): A Dominantly Inherited Cytogenetic Anomaly," Hum. Genet., 77:193-196 (1987).
Jabs, E. W., et al., "Centromere Separation and Aneuploidy in Human Mitotic Mutants: Roberts Syndrome," Mechanisms of Chrom. Dist. and Aneuploidy, 111-118 (Alan R. Liss, Inc., 1989).
Uchida, I. A., et al., "Chromosome Aberrations Induced in vitryo by Low Doses of Radiation: Nondisjunction in Lymphocytes of Young Adults," Am. J. Hum. Genet., 27:419-429 (1975).
Romke, C., et al., "Roberts Syndrome and SC Phocomelia. A Single Genetic Entity," Clinical Genetics, 31:170-177 (1987).
Moorhead, P. S., and Heyman, A., "Chromosome Studies of Patients with Alzheimer Disease," Amer. J. Of Med. Genet., 14:545-556 (1983).
Evans, D. A., et al., "Prevalence of Alzheimer's Disease in a Community Population of Older Persons," JAMA, 262(18):2551-2556 (1989).
Jarvik, L. F., et al., "Chromosomes and Mental Status," Arch. Gen. Psychiatry., 30:186-190 (1974).
Matsuyama, S. S., and Jarvik, L. F., "Hypothesis: Microtubules, a Key to Alzheimer Disease," Proc. Natl. Acad. Sci. USA, 86:8152-8156 (1989).
Nordenson, I., et al., "Chromosomal Abnormality in Dementia of Alzheimer Type," The Lancet, 481-482 (Mar. 1, 1989).
Buckton, K. E., et al., "Chromosome Changes in Alzheimer's Presenile Dementia," J. of Med. Genet., 20:46-51 (1983).
Ward, B. E., et al., "Increased Aneuploidy in Alzheimer Disease," Amer. J. of Med. Genet., 3:137-144 (1979).
White, B. J., et al., "Cytogenetic Studies of Familial and Sporadic Alzheimer Disease," Amer. J. of Med. Genet., 10:77-89 (1981).
Heston, L. L., and Mastri, A. R., "The Genetics of Alzheimer's Disease," Arch. Gen. Psychiatry, 34:976-981 (1977).
Heston, L. L. et al., "Dementia of the Alzheimer Type," Arch. Gen. Psychiatry, 38:1085-1090 (1981).
Lai, F., and Williams, R. S., "A Prospective Study of Alzheimer Disease in Down Syndrome," Arch. Neurol., 46:849-853 (1989).
Pagon, R. A., et al., "Abnormal Skin Fibroblast Cytogenetics in Four Dysmorphic Patients with Normal Lymphocyte Chromosomes," Am. J. Hum. Genet., 31:54-61 (1979).
Goate, A. M., et al., "Predisposing Locus for Alzheimer's Disease on Chromosome 21," The Lancet, 352-355 (Feb. 18, 1989).
Peters, G. B., et al., "Trisomy 21 Mosaicism and Maternal Age Effect," The Lancet, 1202-1203 (May 23, 1987).
Robison, S. H., et al., "Alzheimer's Disease Cells Exhibit Defective Repair of Alkylating Agent-Induced DNA Damage," Anals of Neurology, 21(3):250-258 (1987).
Hardy, J., et al., "Presenile Dementia Associated with Mosaic Trisomy 21 in a Patient with a Down Syndrome Child," The Lancet, 743 (Sep. 23, 1989).
Rowe, I. F., et al., "Presenile Dementia Associated with Mosaic Trisomy 21 in a Patient with a Down Syndrome Child," The Lancet, 229 (Jul 22, 1989).
Harris, W. S. and Goodman, R. M., "Hyper-Reactivity to Atropine in Down's Syndrome," N.E. J. of Med., 279(8):407-410 (1968).
Fitzgerald, P. H., et al., "Evidence for the Repeated Primary Non-Disjunction of Chromosome 21 as a Result of Premature Centromere Division (PCD)," Hum. Genet., 72:58-62 (1986).
Sacks, B. and Smith S., "People with Down's Syndrome can be Distinguished on the Basis of Cholinergic Dysfunction," J. of Neurology, Neurosurgery, and Psych., 52:1294-1295 (1989).
Berg, J. W., et al., "Atropine in Mogolism," Lancet, 2:441-442 (1959).
Lacyk John P.
President and Fellows of Harvard College
Sykes Angela D.
LandOfFree
Method for detecting and treating Alzheimer's disease does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for detecting and treating Alzheimer's disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for detecting and treating Alzheimer's disease will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1777675