Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1994-05-12
1998-12-08
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514824, A61K 31135
Patent
active
058470077
ABSTRACT:
TGF-beta activators and TGF-beta production stimulators are employed to maintain or increase vessel lumen diameter in a diseased or injured vessel of a mammal. Conditions such as restenosis following angioplasty, vascular bypass grafts, transplanted organs, atherosclerosis or hypertension are characterized by a reduced vessel lumen diameter. In a preferred embodiment of the invention, TGF-beta activators and production stimulators inhibit abnormal proliferation of smooth muscle cells. TGF-beta activators or production stimulators that are not characterized by an undesirable systemic toxicity profile at a prophylactic dose are also amenable to chronic use for prophylactic purposes with respect to disease states involving proliferation and/or migration of vascular smooth muscle cells over time. Further provided is a method for determining TGF-beta in vitro, thereby identifying a patient at risk for atherosclerosis and monitoring a recipient that has received one or more administrations of a TGF-beta activator or production stimulator.
REFERENCES:
patent: Re32944 (1989-06-01), Harita et al.
patent: Re33403 (1990-10-01), Stolle et al.
patent: 2914563 (1959-11-01), Allen et al.
patent: 3010965 (1961-11-01), Elpern
patent: 3168565 (1965-02-01), Palopoli et al.
patent: 3288806 (1966-11-01), DeWald et al.
patent: 3634517 (1972-01-01), Palopodi et al.
patent: 3940422 (1976-02-01), Harita et al.
patent: 4070484 (1978-01-01), Harita et al.
patent: 4133814 (1979-01-01), Jones et al.
patent: 4230862 (1980-10-01), Suarez et al.
patent: 4235988 (1980-11-01), Fildes et al.
patent: 4307111 (1981-12-01), Crawley
patent: 4323707 (1982-04-01), Suarez et al.
patent: 4380635 (1983-04-01), Peters
patent: 4418068 (1983-11-01), Jones
patent: 4442119 (1984-04-01), Magarian et al.
patent: 4512762 (1985-04-01), Spears
patent: 4536516 (1985-08-01), Harper et al.
patent: 4696949 (1987-09-01), Toivola et al.
patent: 4824436 (1989-04-01), Wolinsky
patent: 4826672 (1989-05-01), Milius et al.
patent: 4835002 (1989-05-01), Wolf et al.
patent: 4839155 (1989-06-01), McCague
patent: 4859585 (1989-08-01), Sonnenschein et al.
patent: 4879315 (1989-11-01), Magarian et al.
patent: 4929602 (1990-05-01), Harker et al.
patent: 4962091 (1990-10-01), Eppstein et al.
patent: 4973755 (1990-11-01), Grafe et al.
patent: 4990538 (1991-02-01), Harris et al.
patent: 4996225 (1991-02-01), Tiovola et al.
patent: 4997652 (1991-03-01), Wong
patent: 5015666 (1991-05-01), Magarian et al.
patent: 5026537 (1991-06-01), Dodonna
patent: 5032679 (1991-07-01), Brandley et al.
patent: 5043335 (1991-08-01), Kleinschroth et al.
patent: 5047431 (1991-09-01), Schickaneder et al.
patent: 5049132 (1991-09-01), Shaffer et al.
patent: 5053033 (1991-10-01), Clarke
patent: 5075321 (1991-12-01), Schreiber
patent: 5098903 (1992-03-01), Magarian et al.
patent: 5112305 (1992-05-01), Barath et al.
patent: 5116864 (1992-05-01), March et al.
patent: 5120535 (1992-06-01), Marquardt et al.
patent: 5140012 (1992-08-01), McGovern et al.
patent: 5166143 (1992-11-01), Ondetti et al.
patent: 5171217 (1992-12-01), March et al.
patent: 5180366 (1993-01-01), Woods et al.
patent: 5185260 (1993-02-01), Crissman et al.
patent: 5189046 (1993-02-01), Burch et al.
patent: 5189212 (1993-02-01), Ruenitz
patent: 5192525 (1993-03-01), Yang et al.
patent: 5208019 (1993-05-01), Hansson et al.
patent: 5213576 (1993-05-01), Abiuso et al.
patent: 5213580 (1993-05-01), Slepian et al.
patent: 5216126 (1993-06-01), Cox et al.
patent: 5219548 (1993-06-01), Yang et al.
patent: 5221620 (1993-06-01), Purchio et al.
patent: 5226430 (1993-07-01), Spears et al.
patent: 5238714 (1993-08-01), Wallace et al.
patent: 5238950 (1993-08-01), Clader et al.
patent: 5242397 (1993-09-01), Barath et al.
patent: 5254594 (1993-10-01), Niikura et al.
patent: 5268358 (1993-12-01), Fretto et al.
patent: 5270047 (1993-12-01), Kauffman et al.
patent: 5280016 (1994-01-01), Conrad et al.
patent: 5280109 (1994-01-01), Miyazono et al.
patent: 5283257 (1994-02-01), Gregory et al.
patent: 5288711 (1994-02-01), Mitchell et al.
patent: 5296492 (1994-03-01), Shiozawa et al.
patent: 5304541 (1994-04-01), Purchio et al.
patent: 5308622 (1994-05-01), Casscells et al.
patent: 5308862 (1994-05-01), Ohlstein
patent: 5316766 (1994-05-01), Baldus et al.
patent: 5324736 (1994-06-01), Magarian et al.
patent: 5326757 (1994-07-01), Demopoulos
patent: 5328471 (1994-07-01), Slepian
patent: 5340925 (1994-08-01), Lioubin et al.
patent: 5346993 (1994-09-01), Miyazono et al.
patent: 5354562 (1994-10-01), Platz et al.
patent: 5354774 (1994-10-01), Deckelbaum et al.
patent: 5354801 (1994-10-01), O'Toole et al.
patent: 5362424 (1994-11-01), Lee et al.
patent: 5364632 (1994-11-01), Benita et al.
patent: 5380716 (1995-01-01), Conrad et al.
patent: 5384332 (1995-01-01), Fontana
patent: 5385935 (1995-01-01), Tamai et al.
patent: 5389670 (1995-02-01), Fontana
patent: 5391557 (1995-02-01), Cullinan et al.
patent: 5393763 (1995-02-01), Black et al.
patent: 5393772 (1995-02-01), Yue et al.
patent: 5393785 (1995-02-01), Labrie et al.
patent: 5395842 (1995-03-01), Labrie et al.
patent: 5418252 (1995-05-01), Williams
patent: 5426123 (1995-06-01), Fontana
patent: 5436243 (1995-07-01), Sachs et al.
patent: 5439923 (1995-08-01), Cullinan
patent: 5439931 (1995-08-01), Sales
patent: 5441947 (1995-08-01), Dodge et al.
patent: 5441964 (1995-08-01), Bryant et al.
patent: 5441965 (1995-08-01), Sall et al.
patent: 5441966 (1995-08-01), Dodge
patent: 5444164 (1995-08-01), Purchio et al.
patent: 5445941 (1995-08-01), Yang
patent: 5446053 (1995-08-01), Keohane
patent: 5447941 (1995-09-01), Zuckerman
patent: 5451589 (1995-09-01), Dodge
patent: 5451590 (1995-09-01), Dodge
patent: 5453436 (1995-09-01), Ohlstein
patent: 5453442 (1995-09-01), Bryant et al.
patent: 5455275 (1995-10-01), Fontana
patent: 5457116 (1995-10-01), Black et al.
patent: 5457117 (1995-10-01), Black et al.
patent: 5461064 (1995-10-01), Cullinan
patent: 5461065 (1995-10-01), Black et al.
patent: 5462937 (1995-10-01), Cullinan et al.
patent: 5462949 (1995-10-01), Jones et al.
patent: 5462950 (1995-10-01), Fontana
patent: 5468746 (1995-11-01), Casagrande et al.
patent: 5480888 (1996-01-01), Kodama et al.
patent: 5480904 (1996-01-01), Bryant et al.
patent: 5482949 (1996-01-01), Black et al.
patent: 5482950 (1996-01-01), Bryant et al.
patent: 5491173 (1996-02-01), Toivola et al.
patent: 5492926 (1996-02-01), Cullinan et al.
patent: 5492927 (1996-02-01), Glitter et al.
Craig et al. "Modern Pharmacology", published 1982 by Little, Brown and Company (Boston), p. 399.
English language translation of WO 85/00107, Schulze et al., Jan. 85.
Avery's Drug Treatment, 3rd edition, pp. 594-595, 1987.
A. A. Colletta, et al., "Anti-oestrogens induce the secretion of active transforming growth factor beta from human fetal fibroblasts", Br. J. Cancer, 62, 405-409 (1990).
E. R. Edelman, et al., "Effect of controlled adventitial heparin delivery on smooth muscle cell proliferation following endothelial injury", Proc. Natl. Acad. Sci. USA, 87, 3773-3777 (May 1990).
D. J. Grainger, et al., "Effect of Tamoxifen in the Rat Carotid Injury Model in vivo," Manuscript in preparation (1996).
R. A. Majack, et al., "Role of PDGF-A Expresion in the Control of Vascular Smooth Muscle Cell Growth by Transforming Growth Factor-B", The Journal of Cell Biology, 111, 239-247 (1990).
K. Ohmi, et al., "Effect of K252a, A Protein Kinase Inhibitor, on the Proliferation of Vascular Smooth Muscle Cells", Biochem. Biophys. Res. Comm., 173, 976-981 (1990).
G. K. Owens, et al., "Transforming Growth Factor-B-induced Growth Inhibition and Cellular Hypertrophy in Cultured Vascular Smooth Muscle Cells", The Journal of Cell Biology, 107, 771-780 (Aug., 1988).
C. F. Reilly, "Rat Vascular Smooth Muscle Cells Immortalized with SV40 Large T Antigen Possess Defined Smooth Muscle Cell Characteristics Including Growth Inhibition by Heparin", J. Cell. Physiol., 142, 342-351 (1990).
P. L. Weissberg, et al., "Is Vascular Smooth Muscle Cell Proliferation Beneficial?", Lancet, 347, 305-307 (1996).
N. Koyama, et al., "Regulation of Smooth Muscle Cells Migration by a
Grainger David J.
Metcalfe James C.
Weissberg Peter L.
Henley III Raymond
NeoRx Corporation
LandOfFree
Prevention and treatment of pathologies associated with abnormal does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Prevention and treatment of pathologies associated with abnormal, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prevention and treatment of pathologies associated with abnormal will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-177766