Methods for preventing progressive tissue necrosis, reperfusion

Details Methods for preventing progressive tissue necrosis, reperfusion Methods for preventing progressive tissue necrosis, reperfusion

1995-08-18

1998-12-08

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

A61K 3156

Patent

active

058469630

ABSTRACT:
The present invention is related to a method for preventing or reducing the effects of ischemia. The ischemia may be associated with injury or reperfusion injury, such as occurs as a result of infarctions, thermal injury (burns), surgical trauma, accidental trauma, hemorrhagic shock and the like. The invention is also related to methods for preventing or reducing bacterial translocation, adult respiratory distress syndrome, adherence of blood cells and platelets to endothelial cells and pulmonary hypertension. In accordance with the present invention, these conditions are prevented or reduced by administering dehydroepiandrosterone-3-sulfate (DHEAS).

REFERENCES:
patent: 4898694 (1990-02-01), Schwartz
patent: 5001119 (1991-03-01), Schwartz et al.
patent: 5110810 (1992-05-01), Eich et al.
patent: 5162198 (1992-11-01), Eich et al.
patent: 5175154 (1992-12-01), Schwartz et al.
Simon, R.H. et al. (1992). "Adult Respiratory Distress Syndrome," Information: Basic Principles and Clinical Correlates, 2nd Ed., J. Gallin et al., Eds., Raven Press (N.Y.), pp. 999-1016.
Meikle, A.W. et al. (1991). "Adrenal Androgen Secretion and Biologic Effects," Endo-crinol. Metab. Clin. N. Am. 29:2, pp. 381-400.
Vedder, N.B. et al. (1990). "Inhibition of Leukocyte Adherence by Anti-CD18 Monoclonal Antibody Attenuates Reperfusion Injury in the Rabbit Ear," Proc. Nat. Acad. Sci. USA 87:2643-2646.
Dolocek, R. (1989). "Endocrine Changes after Burn Trauma--A Review," Keio J. Med. 38(3):262-276.
Gordon, G. et al. (1987). "Modulation of Growth, Differentiation and Carcinogenesis by Dehydroepiandrosterone," Adv. Enz. Regul. 26:355-378.
Erlich, H.P. (1984). "Anti-inflammatory Drugs in the Vascular Response to Burn Injury," J. Trauma 24(4):311-317.
Robson, M.C. (1990). "Increasing Dermal Perfusion after Burning by Decreasing Thromboxane Production," J. Trauma 20(9):722-725.
Robson, M.C. (1978). "The Effect of Prostaglandins on the Dermal Microcirculation After Burning, and the Inhibition of the Effect by Specific Pharmcological Agents," Annual Meeting of the American Society of Plastic and Reconstructive Surgeons, Hollywood, Florida, Nov. 8, 1978.

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