One-pot process

Details One-pot process One-pot process

1992-05-21

1995-10-31

Geist, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D45702

Patent

active

054630606

ABSTRACT:
Pergolide is produced from 8,9-dihydroelymoclavine by a one-pot process in which it is reacted successively with 1-iodopropane, with a sulfonyl halide, and with an alkali metal thiomethoxide without isolation of intermediate products.

REFERENCES:
patent: 4166182 (1979-08-01), Kornfeld et al.
patent: 4782152 (1988-11-01), Misner
Hutchins et al., J. Org. Chem., 38(10), 1961-62 (1973).
Kametani et al., J. Med. Chem., 12, 694-96 (1969).
Sommer et al., J. Org. Chem., 36(6), 824-28 (1971).
Shamma et al., Tet. Let., (13), 1375-79 (1966).
Manoharan et al., Synthesis, 809-12 (1983).

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