Protein having human plasmin inhibiting activity

Details Protein having human plasmin inhibiting activity Protein having human plasmin inhibiting activity

1994-01-24

1995-10-31

Patterson, Jr., Charles L.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530381, 530382, 435 692, C07K 1447, A61K 3817

Patent

active

054630258

ABSTRACT:
A protein having human plasmin inhibiting activity, substantially equivalent reactivity with human plasmin to a human .alpha..sub.2 -plasmin inhibitor derived from plasma, a binding ability to human fibrin about 1/4 to about 1/3 of that of the human .alpha..sub.2 -plasmin inhibitor derived from plasma, and a molecular weight of about 50,000 to about 77,000.

REFERENCES:
patent: 4346029 (1982-08-01), Collen et al.
Sakata et al. (1980) J. Clin. Invest 65, 290-297.
Reed et al. (1990) Circulation 82, 164-168; Abstract Only.
Holmes et al. (1987) Biochemistry 26, 5133-5140.
Christensen et al. (1992) FEBS Lett. 312(1), 100-104.
Tone et al. (1987) J. Biochem. 102, 1033-1041.
Holmes et al. (1987) J. Biol. Chem. 262, 1659-1664.
Sumi et al., "J. Biochemistry" 106 (4) 703-707 (1989).
Sumi et al., "J. Cellular Biochemistry Suppl.", Vol. 0, Part 13A, p. 95 Jan. 1989, Abst. A338.

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