Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-09-01
1995-10-31
Chang, Ceila
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142272, 5142288, 514253, 514318, A61K 31445
Patent
active
054629489
ABSTRACT:
1-Aryl-3-(4-1piperidyl)-indole derivatives having general formula (I), ##STR1## wherein R.sup.1 is hydrogen, halogen, alkyl, alkoxy, hydroxy, cyano, nitro, alkylthio, trifluoromethyl, trifluoromethylthio, alkylsulfonyl, amino, alkylamino or dialkylaminio; R is optionally substituted phenyl or a heteroaromatic group; and R.sup.2 is hydrogen, cycloalkyl, alkyl or alkenyl, optionally substituted with one or two hydroxy groups, or R.sup.2 is a group of formula (IV), ##STR2## wherein n is an integer of from 2-6; W is O, S or N--R.sup.3, wherein R.sup.3 is H alkyl or cycloalkyl; U is N or CH, Z is --(CH.sub.2).sub.m --, m being 2 or 3, or Z is --CH.dbd.CH--, 1,2-phenylene, or --COCH.sub.2 -- or --CSCH.sub.2 --; V is O,S,CH.sub.2, or NR.sup.4, wherein R.sup.4 is hydrogen, optionally hydroxy substituted alkyl, alkenyl or cycloalkylmethyl; are useful in alleviating, relieving or suppressing withdrawal or abstinence symptons or suppressing the dependency of a drug or a substance of abuse.
REFERENCES:
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Costall Brenda
Perregaard Jens K.
Chang Ceila
H. Lundbeck A/S
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