Antiinflammatory and immunoregulatory pyrimidines, their method

Details Antiinflammatory and immunoregulatory pyrimidines, their method Antiinflammatory and immunoregulatory pyrimidines, their method

1979-10-15

1981-01-20

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544335, 544242, 424263, 546339, 546340, 546341, 546342, 546344, 546346, C07D23926, A61K 31505

Patent

active

042462630

ABSTRACT:
A series of 4-(2-hydroxyethylthiomethyl)pyridines and related compounds, and their pharmaceutically acceptable acid addition salts, having antiinflammatory and immunoregulatory activity are disclosed. Preferred compounds include 4-(2-hydroxyethylthiomethyl)pyridine itself, as well as 4-(2-hydroxyphenylthiomethyl)pyridine, 4-(2-hydroxy-1-propylthiomethyl)pyridine, 4-(3-hydroxy-2-butylthiomethyl)pyridine, 4-(2-hydroxyethylthiomethyl)pyrimidine, the acetate esters corresponding to the above compounds, and 4-(2,3-dihydroxy-1-propylthiomethyl)pyridine.

REFERENCES:
patent: 3818009 (1974-06-01), Taylor et al.
Chemical Abstracts vol. 49, Cols. 336-337, (1955) Abstracting Vejdelek et al. in "Chem. Listy," vol. 47, pp. 49-58 (1953).

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