Additives enhancing topical corticosteroid action

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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A01N 4500, A61K 3156

Patent

active

042462614

ABSTRACT:
Composition and method for enhancing therapeutic effects of corticosteroids to alleviate the symptoms of inflammation and exfoliation such as psoriasis, eczema, seborrheic dermatitis and other inflammatory skin conditions consisting of a solution, cream, lotion, ointment or gel containing as two active ingredients a corticosteroid and an additive are disclosed. The therapeutic composition may include one or more of corticosteroids typically present in a total amount of from 0.01 to 2 percent and one or more of hydroxy acids or related compounds present in a total amount from 0.01 to 2 percent by weight of the total composition. Topical application of the therapeutic composition in a solution, cream, lotion, gel or ointment has been found to achieve a substantial increase in antiinflammatory action of corticosteroids.

REFERENCES:
patent: 3966924 (1976-06-01), Fredriksson
patent: 4144332 (1979-03-01), Voorhees
Chem. Abstracts, vol. 86 (1977), Par. 96,018m.

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