Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1977-04-08
1978-10-10
Roberts, Elbert L.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
2603971, C07J 7100
Patent
active
041196252
ABSTRACT:
The present invention provides a novel process for the manufacture of 17- and 17a-carboxylic acids of the androstane and D-homo-androstane series respectively, of the following partial formula of the ring D ##STR1## wherein R represents a hydrogen atom or an unsubstituted or substituted hydrocarbon radical or a free or functionally modified hydroxyl group, and wherein the carboxyl group can be in the .alpha.- or .beta.-position, and of the salts and functional acid derivatives thereof, in particular their esters. The new process consists in the oxidative degradation of the side chain of corrsponding 20, 21-ketoaldehydes of the pregnane or D-homopregnane series or of the 17.alpha.-pregnane or 17a.alpha.-D-homopregnane series with an organic peracid in an inert solvent, preferably at temperatures between -20 and +30.degree. C, and optionally converting free functional groups present into their derivatives or setting free functional groups from substituents which are derivatives of such groups.
REFERENCES:
patent: 3636010 (1972-01-01), Anner et al.
patent: 3875194 (1975-04-01), Laurent et al.
Ciba-Geigy Corporation
Groeger Theodor O.
Roberts Elbert L.
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