Use of debromohymenialdisine for treating osteoarthritis

Details Use of debromohymenialdisine for treating osteoarthritis Use of debromohymenialdisine for treating osteoarthritis

1995-06-07

1997-01-07

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

A61K 3155

Patent

active

055917402

ABSTRACT:
Disclosed is a method of treating osteoarthritis. The method comprises administering a therapeutic amount of debromohymenialdisine to an individual or animal with osteoarthritis. Debromohymenialdisine is able to slow the joint deterioration and cartilage degradation associated with the disease.

REFERENCES:
Kobayashi, J., et al., ".alpha.-Adrenoceptor Blocking Action of Hymenin, A Novel Marine Alkaloid," Experientia, 44:86-87 (1988).
Pettit, G. R., et al., "Antineoplastic Agents 168 Isolation and Structure of Axinhydantoin," Can. J. Chem., 68:1621-1624 (1990).
Cimino, S., et al., "Isolation and X-Ray Crystal Struction of a Novel Bromo-Compound from Two Marine Sponges," Tetrahedron Lett., 23(7):767-768 (1982).
Kitagawa, I., "Marine Natural Products. XII. On the Chemical Constituents of the Okinawan Marine Sponge Hymeniacidon aldis," Chem. Pharm. Bull., 31(7):2321-2328 (1983).,

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