Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1993-11-23
1997-01-07
Fleisher, Mindy
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4351723, 4352401, 4353201, C12N 510, C12N 508
Patent
active
055916244
ABSTRACT:
The invention described herein allows the production of recombinant retroviruses (retroviral vector particles) from producer cells which are safer and of higher titer than normal. In addition, methods are provided for making helper cells which, when a recombinant retrovirus genome is introduced to make a producer line, produce particles that are targeted toward particular cell types. Methods are also provided for making recombinant retrovirus systems adapted to infect a particular cell type, such as a tumor, by binding the retrovirus or recombinant retrovirus in the particular cell type. Methods are also provided for producing recombinant retroviruses which integrate in a specific small number of places in the host genome, and for producing recombinant retroviruses from transgenic animals.
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Barber Jack R.
Chang Stephen M. W.
Jolly Douglas J.
Respess James G.
Blackburn Robert P.
Chiron Viagene, Inc.
Fleisher Mindy
Kruse Norman J.
Railey II Johnny F.
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