Linear time-of-flight mass spectrometer with high mass resolutio

Details Linear time-of-flight mass spectrometer with high mass resolutio Linear time-of-flight mass spectrometer with high mass resolutio

1997-08-28

1999-05-18

Berman, Jack I.

Radiant energy

Ionic separation or analysis

Ion beam pulsing means with detector synchronizing means

250282, H01J49/40

Patent

active

059052597

ABSTRACT:
The invention relates to a linear time-of-flight mass spectrometer with ionization of analyte substances from surfaces and with improvement in mass resolution through delayed ion acceleration. It especially relates to the design of such a mass spectrometer and to a mass spectrometric measuring procedure for very high mass resolution in the spectrum.
The invention focuses the flight time of the ions in second order by dynamic alteration of at least one of the accelerating voltages applied to the ion source after the start of the delayed acceleration of the ions. In a most simple method, an easily generated exponential decay of the accelerating field in front of the sample support can be used. In computer simulations, resolutions of much greater than one million have been obtained.

REFERENCES:
patent: 5504326 (1996-04-01), Reilly et al.
patent: 5777325 (1998-07-01), Weinberger et al.
Steven M. Colby et al, Space-Velocity Correlation Focusing, Analytical Chemistry, vol. 68, No. 8, Apr. 15, 1996.
Robert S. Brown et al., Matrix Resolution Improvement by Incorporation of Pulsed Ion Extraction in a Matrix-Assisted Laser Desorption/Ionization Linear Time-of-Flight Mass Spectrometer, Analytical Chemistry, vol. 67, No. 13, Jul. 1, 1995.
Eric D. Erickson et al., Mass Dependence Of Time-Lag Focusing In Time-Of-Flight Mass Spectrometry-An Analysis, International Journal of Mass Spectrometry and Ion Processes, vol. 97, pp. 87-106, 1990.
William B. Martin et al., The Importance of the Time-Lag Parameter in a Laser/Time-Of-Mass Spectrometer, International Journal of Mass Spectrometry and Ion Processes, vol. 77, pp. 203-221, 1987.

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