Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1995-05-08
1999-05-18
Allen, Marianne P.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
530350, C12N15/18
Patent
active
059051426
ABSTRACT:
PDGF B-chain polypeptides characterized by the substitution or deletion of a lysine or arginine residue at position 27, 28, 32, 79, 80 or 81 of native B-chain are disclosed. Also disclosed are PDGF-like proteins containing the B-chain polypeptides. The polypeptides and proteins may be produced through the use of cultured cells transfected or transformed to express DNA molecules that encode the polypeptides. The PDGF-like proteins are useful as components of cell culture media and for accelerating the healing of wounds.
REFERENCES:
patent: 4845075 (1989-07-01), Murray et al.
patent: 5045633 (1991-09-01), Murray et al.
patent: 5512545 (1996-04-01), Brown et al.
Johnsson et al., "The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor," EMBO J. 3(5):921-928, 1984.
Betsholtz, et al., "cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines," Nature 320:695-699, 1986.
Allen Marianne P.
ZymoGenetics Inc.
LandOfFree
Protease resistant PDGF and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Protease resistant PDGF and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protease resistant PDGF and methods of use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1760101