Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-02
1999-05-18
Geist, Gary
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K31/44
Patent
active
059050837
ABSTRACT:
Disclosed are methods for rectifying or ameliorating abnormal responses of mammalian immune systems, such as rheumatoid arthritis. Also disclosed are methods for modifying normal responses of the mammalian immune system. Further disclosed are methods for accomplishing the foregoing by administering to a mammal a prolactin reducer and/or enhancer at a pre-determined time or times during a 24-hour period that results in modification of the mammal's abnormal prolactin profile so that it approaches or conforms to the prolactin profile of a young, healthy mammal of the same species (or to a standard profile generated from such individuals). Additionally, methods of upregulating or augmenting an immune response in a mammal are disclosed.
REFERENCES:
patent: 4310535 (1982-01-01), Pierpaoli
patent: 5145837 (1992-09-01), Feyen et al.
patent: 5213808 (1993-05-01), Bar-Shalom et al.
patent: 5344832 (1994-09-01), Cincotta et al.
patent: 5519047 (1996-05-01), Shelby et al.
patent: 5696128 (1997-12-01), Cincotta et al.
Neri et al., Cancer, 73:3015-3019, 1994.
Regelson et al., Cancer Investigation, 5:379-385, 1987.
Jara, et al., Semin Arthritis Rheum., 5:273-84, 1991.
Holaday, J.W., Klin Wochenschr, 69:13-19, 1991.
Lopez-Karpovitch et al., AJRI, 31:32-39, 1994.
Gutierez et al., Rev. Rheum. Ed. Fr., 61:278-85, 1994.
Mattsson et al., Clin. Exp. Immunol., 85:41-47, 1991.
Rev Rhum Ed Fr, vol. 61 (4), Gutierez et al., "Prolactin, a link between the neuroendocrine and immune systems. Role in the pathogenesis of rheumatic disease", Apr. 1994, pp. 278-285, abstract.
Semin Arthiritis Rheum, vol. 20, No. 5, Jara et al., "Prolactin, Immunoregulation, and Autoimmune Disease", 1991, pp. 273-284, abstract.
Clin Exp Immunol, vol. 85(1), Mattsson et al., "Maintained Pregnancy Levels of Estrogen Afford complete Protection from Post-Partum Exacerbation of Collagen-Induced Arthritis", 1991, pp. 41-47, abstract.
Adejuwon et al., "Comparative Prolactine . . . Users", Contraception, 25/6, pp. 613-618, abstract, 1982.
Cowden et al., "Tests of Prolactin . . . Prolactinomas", Lancet, 1/8127, pp. 1155-1158, abstract, 1979.
Jara et al., Prolactin, . . . Diseases, Seminars in Arthritis & Rheumatism, vol. 20, No. 5, pp. 273-284, Apr. 1991.
Dijkstra et al., Trends Pharmacol. Sci., 14:124-129, 1993.
Jara et al., Ame. J. of the Med. Sci., 303:222-226, Apr. 1992.
Kukhtevich et al., The Genuine Article, abstract no. FX734, Terapevtichdkii Ardhiv, 63:99-101, 1991.
Folomeev et al., Biological Abstracts, vol. 90, abstract No. 75731, Ter Arkh, 62:62-63, 1990.
Lissoni et al., Eur F Cancer, 30:167-170, 1994.
Barnett et al., Postgraduate Medical Journal, 56:11-14, 1980.
Lissoni et al., Oncology, 51:344-347, 1994.
Meier et al., Experientia 48, Birkunser Verlag. CH-1010 Basal, Switzerland, 148-153, 1992.
Lissoni, Oncology, 52:163-166, 1995.
Berczi, I. et al., Acta Endocrinologica, 98:506-513, 1980.
Berczi, I., Dev. Comp. Immunol., 13:329-341, 1989.
Bernton, E.S. et al., Science, 239:401-4, 1989.
Besedovsky, H.O. et al., J. Immunol., 135:750s-4s, 1985.
Blalock, J.E., Physiol. Rev., 69:1-32, 1989.
Blizhakov, J. Med., N.Y., 1980, 11(2/3):81-105.
Gala. R.R., Proc. Soc. Exp. Biol. Med. 198:513-27, 1991.
Gutierrez, M.A., Rev. Rhum. Engl. Ed., 1994, 61/4, 261-267.
Hedner et al., Am. J. Ophthalmology, Oct. 1985, 618-19.
Holaday, J.W., "Neuroendocrine -- Immune Interaction", 1991, 69 (Suppl. XXVI): 13-19.
Lopez-Korpovitch et al., AJRI, 1994, 31:32-39.
McMurray, R., et al., J. Immunol. 147:3780-7, 1991.
Parraquez et al., J. Dev. Physiol. (1991) 16(2): 57-62.
Nicoletti, I. et al., J. Reprod. Immunol.,15:113-121, 1989.
Reder, A.T. and Lowy, M.T., J. Neurological Sci., 117:192-196, 1992.
Reber, P.M., Am J. Med., 1993 95 (6): 637-644.
Reichlin, S., NEJM 329:1246-53, 1993.
Rovensky, J. et al., Int. J. Immunopharmac., 13:267-272, 1991.
Vidaller, A. et al., Clin. Immunol. Immunopathol, 38:337-43, 1986.
Vidaller, A. et al., J. Clin. Immunol., 12:210-5, 1992.
Jara et al., "Prolactin, Immunoregulation, and Autoimmune Diseases", Semin. Arthritis Rheum., vol. 20, No. 5, abstract, 1991.
Gutierez et al., "Prolactin, a link between the neuroendocrine and immune systems. Role in the pathogenesis of rheumatic diseases", Rev. Rhum. Ed. Fr, 61(4), abstract, 1994.
Mattsson et al., "Maintained Pregnancy Levels of Estrogen Afford Complete Protection from Post-Partum Exacerbation of Collagen-Induced Arthritis", Clin. Exp. Immunol. 85(1), abstract, 1991.
Cincotta Anthony H.
Meier Albert H.
Ergo Science Incorporated
Geist Gary
Keys Rosalynd
LandOfFree
Method of treating rheumatoid arthritis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of treating rheumatoid arthritis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating rheumatoid arthritis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1759644