Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-06-19
1993-11-02
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544231, 544349, 548518, 548531, 548561, 548562, 558393, A61K 31495, C07D48720
Patent
active
052583821
ABSTRACT:
Tetrahydropyrrolo[1,2-a]pyrazine-4-spiro-3'-pyrrolidine derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are independently hydrogen, halogen, trifluoromethyl, alkyl having 1 to 6 carbon atoms, alkoxy having 1 to 6 carbon atoms, or nitro, and R.sup.3 is hydrogen, halogen or alkyl having 1 to 6 carbon atoms, and pharmaceutically acceptable salts thereof, processes for preparation thereof, and pharmaceutical composition containing the same. Said compounds and their salts show excellent aldose reductase inhibitory activity and are useful for the prevention and treatment of diabetic complications.
REFERENCES:
patent: 4855298 (1989-08-01), Yamada et al.
Chemical Abstracts, vol. 82, No. 23 (Jun. 1975); Abstract 156398q Moritomo et al; p. 621.
Fujitani Buichi
Murata Makoto
Negoro Toshiyuki
Ono Yoshiyuki
Ueda Shozo
Bernhardt Emily
Dainippon Pharmaceutical Co., Ltd.
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