Fluorinated pentene diamine derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

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2601125R, 560 39, 560 41, 562448, 562449, 562561, 562565, 564157, 564159, 564164, 564182, 564187, 564197, 564198, 564215, 564509, 424177, 424314, 424319, 424325, C07C10124, C07C 8726

Patent

active

044396198

ABSTRACT:
Fluorinated alkenylene diamine compounds are inhibitors of ornithine decarboxylase enzyme in vivo and have the following formula: ##STR1## wherein: R.sub.a represents hydrogen or R.sub.2, where R.sub.2 is as defined below;

REFERENCES:
patent: 2662915 (1953-12-01), Lontz
patent: 4323704 (1982-04-01), Metcalf
patent: 4325961 (1982-04-01), Kollonitsch
patent: 4326071 (1982-04-01), Bey
Mamont, Biochem. Biophys. Res. Comm., 81, p. 58, (1978).
Metcalf, J. Am. Chem. Soc., 100, p. 255, (1978).
Kollonitsch, Nature, 274, p. 906, (1978).

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