Demonstration by in vivo measurement of reflection ultrasound an

Details Demonstration by in vivo measurement of reflection ultrasound an Demonstration by in vivo measurement of reflection ultrasound an

1991-12-26

1993-07-20

Jaworski, Francis

Surgery

Truss

Pad

12866103, A61B 800

Patent

active

052284450

ABSTRACT:
The invention involves a treatment process for improving the intrinsic quality of bone in osteoporotic patients. This can reduce the frequency of spinal fractures by inducing formation of bone which is mechanically stronger than that which it replaces. The process preferably comprises: administering an enteral form of sodium fluoride to maintain an individual's serum fluoride level from about 100 to about 200 ng/ml with a circadian fluctuation of less than about 75 ng/ml, and dietarily supplementing said individual with absorbable calcium (preferably calcium citrate). In one embodiment, sodium fluoride administration is interrupted temporarily (for about 30 to about 60 days in a 13 or 14 month cycle) to prevent loss of fluoride effectiveness and avert impaired mineralization of bone. Calcium is preferably maintained by an enteral dose of about 400 mg calcium twice daily. A vitamin D preparation may also be administered to the individual to further enhance bone strengthening. As a method for assessing response, periodic noninvasive in vivo measurements of intrinsic bone quality are made by reflection ultrasound, and the treatment regimen is maintained, altered or discontinued based on clinical assessment of the results. In this way, clinical response to the treatment is evaluated to guide its continued application.

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This is a continuation-in-part of U.S. patent application Ser. No. 07/539,993, filed Jun. 18, 1990 and now abandoned. Research leading to development of the present invention was supported in part by grants RO1-AR16061 and MO1-RR00633 from the National Institutes of Health, Department of Health and Human Services, United States of America, and from Vitel, Inc.

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