Monoclonal antibodies binding platinum complexes

Details Monoclonal antibodies binding platinum complexes Monoclonal antibodies binding platinum complexes

1987-07-15

1991-10-01

Richter, Johann

Drug, bio-affecting and body treating compositions

Lymphokine

424 86, 424 87, 43524027, 43524026, A61K 3940, A61K 3942, A61K 3944, C12N 500

Patent

active

050532260

ABSTRACT:
The present invention relates to monoclonal antibodies specifically binding platinum (II) complex. The monoclonal antibodies of the present invention are characteristically produced by antibody-producing cell lines such as hybridomas. These cell lines may result, for example, from fusion of a neoplastic cell with an antibody-producing animal cell obtained from an animal immunized against a platinum (II) complex. The cellular fusion products include cell lines forming monoclonal antibody specifically binding platinum (II) complex in competition with an antibody produced by: hybridoma strain 1C.sub.1 H.sub.2 A.sub.5, deposited with the American Type Culture Collection, Rockville, MD on May 1, 1987 and having ATCC accession number HB 9411; strain 3A.sub.2 A.sub.1 ; strain 1A.sub.6 A.sub.2 ; strain 3A.sub.6 B.sub.1 or strain 1B.sub.1. The cell lines of the present invention are preferably continuous murine hybridoma cell lines which secrete recoverable quantities of monoclonal antibody, particularly a monoclonal antibody which is of an IgG or IgM isotype.

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