5-Substituted 1-(4-(1-pyrrolidinyl)-2-butynyl)-2-pyrrolidinones,

Details 5-Substituted 1-(4-(1-pyrrolidinyl)-2-butynyl)-2-pyrrolidinones, 5-Substituted 1-(4-(1-pyrrolidinyl)-2-butynyl)-2-pyrrolidinones,

1988-01-25

1988-09-20

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142355, 514252, 514326, 514365, 514422, 514423, 544 585, 544141, 544372, 546208, 548146, 548524, 548534, 548537, A61K 3140, A61K 31535, C07D20728, C07D41306

Patent

active

047726016

ABSTRACT:
There are disclosed compounds of the formula ##STR1## where R.sub.1 is loweralkoxycarbonyl, --CH.sub.2 OH or --CONR.sub.3 R.sub.4, R.sub.3 and R.sub.4 being independently hydrogen, loweralkyl or arylloweralkyl; and R.sub.2 is --CH.sub.2 CH.dbd.CH.sub.2, ##STR2## R.sub.5 and R.sub.6 being independently loweralkyl or alternatively the group --NR.sub.5 R.sub.6 as a whole being ##STR3## R.sub.7 being hydrogen, loweralkyl or arylloweralkyl; which are useful for enhancing cholinergic activity in mammals and hence for the treatment of various memory dysfunctions characterized by decreased cholinergic function such as Alzheimer's disease.

REFERENCES:
patent: 3444185 (1969-05-01), Nau
patent: 3565794 (1971-02-01), Pigache

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