Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1986-02-03
1988-09-20
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
424 86, 435 7, 435 68, 4351721, 43524027, 435805, 435810, 436548, 436811, 436531, 530324, 530325, 530326, 530327, 530387, 530806, 530807, 530808, C07K 710, G01N 33545, G01N 33577, C12Q 170
Patent
active
047725478
ABSTRACT:
The present disclosure relates to synthetic peptides derived from the conserved region of the HTLVIII envelope proteins. These peptides are useful as reagents for immunoassays for detection of AIDS antibodies, as components of immunogenic compositions useful as vaccines, and for the production of anti-bodies selective to said envelope protein and methods for detecting the presence of AIDS antibodies in biological fluid samples.
REFERENCES:
patent: 4520113 (1985-05-01), Gallo et al.
patent: 4591552 (1986-05-01), Neurath
patent: 4629783 (1986-12-01), Cosand
Meusing et al., "Nucleic Acid Structure and Expression of the Human AIDS/Lymphadenopathy Retrovirus", Nature 313 (2/7/85) 450-8.
Veronese et al., "Characterization of GP41 as the Transmembrane Protein Coded by the HTLV-III/LAV Envelope Gene", Science 229 (9/27/85) 1402-5.
Pavletti et al., "Application of a Modified Computor Algorithm in Determining Potential Antigenic Determinents Associated with the AIDS Virus Glycoprotein", Analytical Biochemistry, 151 (12/85) 540-6.
Cabradilla et al., "Serodiagnosis of Antibodies to the Human AIDS Retrovirus with a Baterially Synthesized Env Polypeptide", Bio/Technology, 4 (2/86) 128-133.
Chang et al., "Expression of Escherichia coli of Open Reading Frame Gene Segments of HTLV-III, Science 228 (4/5/85) 93-6.
Chang et al., "Detection of Antibodies to Human T-Cell Lymphotropic Virus-III (HTLV-III) with an Immunoassay Employing a Recombinant Escherichia coli-Derived Viral Antigenic Peptide", Bio/Technology, 3 (10/85) 905-9.
Robert-Guroff et al., "A Monoclonal Antibody Specific for a 52,000-Molecular-Weight Human T-Cell Leukemia Virus-Associated Gycoprotein Expressed by Infected Cells", J. Virology 53 (1/85) 214-220.
Mortimer et al., "Which Anti-HTLV III/LAV Assays for Screening and Conformatory Testing?", Lancet (10/19/85) 873-7.
Crowl et al., "HTLV-III env Gene Products Synthesized in E. coli are Recognized by Antibodies Present in the Sera of AIDS Patients", Cell 41 (7/85) 979-86.
Chang et al., "An HTLV-III Peptide Produced by Recombinant DNA is Immunoreactive with Sera from Patients with AIDS", Nature, 315 (5/9/85) 151-4.
Wang et al., "Detection of Antibodies to Human T-Lymphotropic Virus Type III by Using a Synthetic Peptide of Z1 Amino Acid Residues Corresponding to a Highly Antigenic Segment of GP41 Envelope Protein", Proc. Nat'l. Acad. Sci. USA, 83 (8/86) 6159-63.
Barre-Sinoussi et al., Science 220:868 (1983).
Bolivar et al., Gene 2:95 (1977).
Casadaban et al., J. Mol. Biol. 138:179 (1980).
Kitchen et al., Nature 312:367 (1984).
Lacal et al., Proc. Natl. Acad. Sci. USA 81:5305 (1984).
Lomedico et al., Nature 312:458 (1984).
Montagnier et al., Human T-Cell Leukemia/Lymphoma Viruses, Cold Spring Harbor, New York, Conference Date Sep. 14-16, 1983, Published 1984.
Sarngadharan et al., Science 224:506 (1984).
Schupbach et al., Science 224:503 (1984).
Sutcliffe, Nucleic Acids Res. 5:2721 (1978).
Ratner et al., "Complete Nucleotide Sequence of the AIDS Virus, HTLV-III", Nature, vol. 313, pp. 277-284, Jan. 24, 1985.
Sanchez-Pescador, R. et al., "Nucleotide Sequence and Expression of an AIDS-Associated Retrovirus (ARV-2)", Science, vol. 227, pp. 484-492, Feb. 1, 1985.
Wain-Hobson, S. et al., "Nucleotide Sequence of the AIDS Virus, LAV", Cell, vol. 40, pp. 9-17, Jan. 1985.
Kiyokawa, T. et al., "Envelope Proteins of Human T-Cell Leukemia Virus: Expression in Escherichia coli and its Application of Studies of Env. Gene Functions", Proc. Natl. Acad. Sci. USA, vol. 81, pp. 6202-6206, Oct. 1984.
Gallo Robert C.
Heimer Edgar P.
Reddy Premkumar E.
Wong-Staal Flossie
Dulak Norman C.
Gould George M.
Hoffmann-La Roche Inc.
Nucker Christine M.
Saxe Jon S.
LandOfFree
HTLV-III envelope peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with HTLV-III envelope peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and HTLV-III envelope peptides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1748273