Process for the manufacture of 7.beta.-amino-3-cephem-3-ol-4 car

Details Process for the manufacture of 7.beta.-amino-3-cephem-3-ol-4 car Process for the manufacture of 7.beta.-amino-3-cephem-3-ol-4 car

1976-12-02

1979-04-03

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 22, 424246, 260239A, C07D50102

Patent

active

041478649

ABSTRACT:
7.beta.-amino-3-cephem-3-ol-4-carboxylic acid compounds of the formula ##STR1## wherein R.sub.1.sup.a represents hydrogen or an amino protective group R.sub.1.sup.A and R.sub.1.sup.B represents hydrogen or an acyl group Ac, or R.sub.1.sup.a and R.sub.1.sup.b together represent a bivalent amino protective group, R.sub.2 represents hydroxyl or a radical R.sub.2.sup.A which together with the carbonyl grouping --C(.dbd.O)-- forms a protected carboxyl group and R.sub.3 represents hydrogen, lower alkyl or a hydroxyl protective group, and 1-oxides or 3-cephem compounds of the formula IA, and the corresponding 2-cephem compounds are prepared in that a compound of the formula ##STR2## wherein R.sub.1.sup.a, R.sub.1.sup.b and R.sub.2.sup.A have the meanings mentioned under formula IA, R.sub.3.sup.o represents lower alkyl or a hydroxyl protective group and Y represents a group which is removed, is treated with a base; also comprised are intermediate products.

REFERENCES:
patent: 3840556 (1974-10-01), Kukulja
patent: 3860577 (1975-01-01), Kukulja
patent: 3989695 (1976-11-01), Scartazzini et al.
patent: 4007202 (1977-02-01), Verweij
patent: 4073902 (1978-02-01), Scartazzini et al.

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