2-Amino-3,4-dihydropyridines used to effect coronary vessel dila

Details 2-Amino-3,4-dihydropyridines used to effect coronary vessel dila 2-Amino-3,4-dihydropyridines used to effect coronary vessel dila

1975-01-28

1977-01-11

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424251, 424258, 424263, A61K 31455

Patent

active

040027627

ABSTRACT:
3-Substituted 2-amino-3,4-dihydropyridine-3-carboxylic acid esters are produced by reacting 2-amino-1,4-dihydropyridine-3-carboxylic acid esters with an alkylating agent in the presence of an inert organic solvent at a temperature of from 20.degree. C to 200.degree. C. The compounds, of which 2-amino-3,6-dimethyl-4-phenyl-3,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester is a typical embodiment, possess antihypertensive and coronary dilating properties.

REFERENCES:
patent: 3708489 (1973-01-01), Rucker et al.
patent: 3773773 (1973-11-01), Bossert
patent: 3775422 (1973-11-01), Bossert et al.
patent: 3925395 (1975-12-01), Meyer et al.

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