Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1989-04-12
1989-10-17
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544143, A61K 31535
Patent
active
048747610
ABSTRACT:
4-Arylcarbonyl-1-[(4-morpholinyl)-lower-alkyl]-1H-indoles, useful as analgesic agents, are prepared by reaction of a 3-arylcarbonyl-2-methylnitrobenzene with DMF dimethyl acetal; reductive cyclization of the product with hydrogen over a catalyst; and N-alkylation of the resulting 4-arylcarbonylindole with an appropriate 4-(halo-lower-alkyl)morpholine in the presence of a strong base.
REFERENCES:
patent: 3945029 (1976-03-01), Deschamps et al.
patent: 4581354 (1986-04-01), Bell
Croce, Ann. di Chem., 63, 29-35 (1973).
Bell Malcolm R.
D'Ambra Thomas E.
Covington Raymond
DuPont Paul E.
Raymond Richard L.
Sterling Drug Inc.
Webb William G.
LandOfFree
4-arylcarbonyl-1-[(4-morpholinyl)-lower-alkyl]-1H-indoles does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 4-arylcarbonyl-1-[(4-morpholinyl)-lower-alkyl]-1H-indoles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-arylcarbonyl-1-[(4-morpholinyl)-lower-alkyl]-1H-indoles will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1743774