Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H.su

Details Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H.su Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H.su

1984-04-16

1986-07-15

Lesmes, George F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

260239BA, 2602455, 544 60, 544124, 544134, 544367, 546209, 546277, 514183, 514218, 514222, 514227, 514252, 514326, 514342, 514362, C07D28510, C07D41710, C07D41712, C07D41714

Patent

active

046007792

ABSTRACT:
Histamine H.sub.2 -receptor antagonists of the formula ##STR1## wherein A, m, Z, n and R.sup.1 are as defined herein, and their nontoxic pharmaceutically acceptable salts, hydrates and solvates are novel anti-ulcer agents which are prepared by ring closure of a substituted ethanediimidamide of the formula ##STR2##

REFERENCES:
patent: 4393508 (1983-07-01), Crenshaw et al.
patent: 4440933 (1984-04-01), Montzku
patent: 4528375 (1985-07-01), Crenshaw et al.
patent: 4528377 (1985-07-01), Crenshaw et al.
patent: 4528378 (1985-07-01), Crenshaw et al.
Kromin, A. P. et al., J. Org. Chem., 40, (19), pp. 2749-2752, (1975).

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