Site-specific homogeneous modification of polypeptides

Details Site-specific homogeneous modification of polypeptides Site-specific homogeneous modification of polypeptides

1987-12-23

1990-02-27

Rosenberg, Peter D.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

424 851, 435 695, 514 8, 530351, 530397, 530410, C12D 2100

Patent

active

049045849

ABSTRACT:
A homogeneously modified protein is provided having one or more selected naturally occurring lysine residues replaced by a suitable amino acid, or having one or more lysine residues substituted for other amino acids or inserted into a polypeptide sequence, leaving selected lysine residues having .epsilon.-amino groups in the protein and coupling amine reactive compounds to selected lysine residues. Methods for producing the selected homogeneously modified proteins and pharmaceutical compositions containing such proteins are provided.

REFERENCES:
patent: 4738844 (1988-04-01), Bell
patent: 4751077 (1988-06-01), Bell
patent: 4753795 (1988-06-01), Bell
patent: 4762914 (1988-08-01), Auron
patent: 4769233 (1988-09-01), Bell

Affiliated with

Also associated with

Rating

Site-specific homogeneous modification of polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Site-specific homogeneous modification of polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Site-specific homogeneous modification of polypeptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-173651