N,N-Di-(n-Propyl)dopamine derivatives

Details N,N-Di-(n-Propyl)dopamine derivatives N,N-Di-(n-Propyl)dopamine derivatives

1977-03-28

1985-07-16

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

564374, 514929, C07C 9132, A61K 31138

Patent

active

045296049

ABSTRACT:
N,N-Di-(n-propyl)dopamine derivatives having peripheral dopamine receptor agonist activity prepared by synthetic routes known for phenethylamines. The renal vasodilator effect of 3,4-dihydroxy-N,N-di(n-propyl)-phenethylamine is potentiated by the concomitant administration of the .beta.-blocker propranolol.

REFERENCES:
patent: 3686167 (1972-08-01), Fujimura et al.
patent: 4219568 (1980-08-01), Goldberg et al.
Volkman et al., Federation Proceedings, V.36, No. 3, Mar. 1, 1977, AB No. 4093, p. 1049.
Kindler et al., CA 45, 1970-1971 (1951).
Genos et al., J. Med. Chem. 18, 1194-1200 (1975).
Cannon et al., J. Med. Chem. 18, 1212-1216 (1975).

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