Substituted 1-azabicyclo(3.2.0)hept-6-en-2-one-7-carboxylic acid

Details Substituted 1-azabicyclo(3.2.0)hept-6-en-2-one-7-carboxylic acid Substituted 1-azabicyclo(3.2.0)hept-6-en-2-one-7-carboxylic acid

1982-04-19

1985-07-16

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546198, 544333, 548206, 548202, 2602452T, 2602452R, 548512, 548515, 548336, 514423, 514424, 514375, 514365, 514781, 514339, C07D20512, A61K 31395

Patent

active

045295972

ABSTRACT:
Disclosed are substituted 1-azabicyclo [3.2.0]-hept-6-en-2-one-7-carboxylic acids (I) and their pharmaceutically acceptable salts and esters which are useful as antibiotics. ##STR1## wherein R is hydrogen, and, inter alia, unsubstituted and substituted alkyl, aryl, aralkyl; R.sup.8 is, inter alia, unsubstituted and substituted alkyl, alkenyl, aryl, and aralkyl. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

REFERENCES:
patent: 4235917 (1980-11-01), Christensen et al.
patent: 4235922 (1980-11-01), Ratfliffe et al.

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