Production of 2-(2-aminothiazole-4-yl)-2-(syn)-methoxyimino acet

Details Production of 2-(2-aminothiazole-4-yl)-2-(syn)-methoxyimino acet Production of 2-(2-aminothiazole-4-yl)-2-(syn)-methoxyimino acet

1981-07-24

1985-03-05

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D27740

Patent

active

045032343

ABSTRACT:
Process for the production of 2-(2-aminothiazole-4-yl)-2-(syn)-methoxyimino acetic ester. First 4-chloroacetoacetic ester is oximized and then the resultant chlorohydroxyimino ester, in solution form, reacted with thiourea to produce 2-(2-aminothiazole-4-yl)-2-(syn)-hydroxyimino acetic ester. The latter is methylated with dimethyl sulfate using phase transfer catalysis.

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