Spergualin-related compounds and process for the preparation the

Details Spergualin-related compounds and process for the preparation the Spergualin-related compounds and process for the preparation the

1983-08-18

1985-07-16

Sneed, Helen M. S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

548342, 548504, 548538, C07F 500, C07F 700

Patent

active

045295492

ABSTRACT:
This invention relates to a novel spergualin-related compound and a process for the production thereof. The novel compound, which has a high antitumor activity, is represented by the general formula ##STR1## wherein R.sub.1 represents a hydrogen atom, hydroxyl group, or an aliphatic acyloxy group having 1 to 10 carbon atoms, R.sub.2 represents an amino acid residue (except for the residue of .alpha.-hydroxyglycine) formed by removing one hydrogen atom and hydroxyl group from respectively the .alpha.- or .omega.-amino group and the .alpha.-carboxyl group of an .alpha.- or .omega.-amino acid, said amino acid residue forming acid amide linkages with the adjacent carbonyl group and amino group, and m is an integer of 4 to 6.

REFERENCES:
patent: 3737443 (1973-06-01), Hashimoto et al.
patent: 3935266 (1976-01-01), Hashimoto et al.
patent: 3937805 (1976-02-01), Harrison
patent: 4416899 (1983-11-01), Umezawa et al.
Takeuchi et al., J. Antibiotics 34(12), 1619-1621, (1981).
Umezawa et al., J. Antibiotics 34(12), 1622-1623, (1981).
Kondo et al., J. Antibiotics 34(12), 1625-1627, (1981).

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