Process for the resolution of 1-aminoindanes

Details Process for the resolution of 1-aminoindanes Process for the resolution of 1-aminoindanes

1986-02-03

1989-05-23

Hines, Robert V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

562401, 562446, 564428, 26050111, C07C 5700

Patent

active

048332739

ABSTRACT:
An improved process for the resolution of 1-aminoindanes into the R-isomer on a large scale is described. The resolving agent used in the process is R-N-acetyl-3,4-dimethoxyphenylalanine. The process is of intermediates in the production of certain adenosines and their pharmaceutically acceptable acid addition salts. The adenosines have desirable central nervous system and cardiovascular activities such as antipsychotic, sedative, antihypertensive, and antianginal.

REFERENCES:
patent: 3028430 (1962-04-01), Gillingham
patent: 3167566 (1965-01-01), Overby
patent: 3734952 (1973-05-01), Krubiner
patent: 3919316 (1975-11-01), Molloy
patent: 3969397 (1976-07-01), Kaiser et al.
patent: 4132737 (1979-01-01), Molloy
patent: 4501735 (1985-02-01), Trivedi et al.
Bull. Chim. & Farm. 115: 489-500 (1976) translated.

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