Substituted quinolines and isoquinolines as calcium channel bloc

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514310, 514311, 514313, 514314, 540597, 546143, 546146, 546148, 546149, 546150, 546159, 546162, 546165, 546166, A61K 3147, C07D21722, C07D21516, C07D21502

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057671290

ABSTRACT:
The present invention relates to novel substituted quinolines and isoquinolines and derivatives thereof useful in the treatment of neurological disorders. Methods of preparing the compounds, intermediates useful in the preparation and pharmaceutical compositions containing the compounds are also included. The compounds are useful in treating pain, cerebral ischemia, and other cerebrovascular disorders.

REFERENCES:
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Yamada, et al., Chemical Abstract 96:85389p.
Shterev and Kaneti, Chemical Abstract 108:142832v.
Bourquin, et al., Archiv der Pharmazie, 295(5):383-400 (1962).
Brack, Arzneimittel-Forsch. 12, 133-144 (1962).
Roush et al, "Search for new alkaloids in Pachycereus werbi by tandem mass spectrometry", Anal. Chem. (1985), 57 (1), 109-114.
Hara et al, Tetrahedron Lett. (1988), (29) (31), 3815-16.

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