Method for treating actinic keratosis with cytotoxic agents

Details Method for treating actinic keratosis with cytotoxic agents Method for treating actinic keratosis with cytotoxic agents

1987-12-02

1989-07-18

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514947, A61K 31505

Patent

active

048494267

ABSTRACT:
A method for treating actinic keratosis comprising applying an effective amount of a cytotoxic drug dispersed in a pharmaceutically acceptable vehicle containing a penetrating solvent for the drug, the drug being applied to the skin area having the actinic keratosis growth without occlusion in pulses at an interval of once every from 3 to 30 days and preferably at an interval of from 4 to 14 days. Optimally, the penetrating solvent is free from toxic effects, such as propylene glycol, AZONE.RTM. or similar substituted azacycloalkyl-2-ones, tertiary amine oxides, and the like.

REFERENCES:
patent: 3989816 (1976-11-01), Rajadhyaksha
patent: 4423040 (1983-12-01), Rajadhyaksha
patent: 4636509 (1987-01-01), Phillips et al.
patent: 4705791 (1987-11-01), Benneche et al.
Remington's Pharmaceutical Sciences, 15th Ed., 1975, p. 1079.

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