Substitute indole and benzimidazole derivatives

Details Substitute indole and benzimidazole derivatives Substitute indole and benzimidazole derivatives

1991-12-16

1993-08-10

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514256, 514259, 514260, 514270, 514272, 514273, 514274, 514275, 544117, 544122, 544123, 544243, 544244, 544278, 544279, 544280, 544284, 544295, 544300, 544310, 544315, 544316, 544317, 544318, 544319, 544320, 544321, 544322, 544331, 544333, A61K 31505, C07D491048, C07D491052, C07D23920

Patent

active

052349233

ABSTRACT:
Novel compounds are disclosed having the formula ##STR1## or its isomer ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and X are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.

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Karnail S. Atwal et al., "Substituted 1,4-Dihydropyrimidines, 3, Synthesis of Selectively Functionalized 2-Hetero-1,4 dihydropyrimidines", J. Org. Chem., 1989, 54, pp. 5898-5907.
Peter Buhlmayer et al., "Nonpeptidic Angiotensin II Antagonists: Synthesis and in Vitro Activity of a Series of Novel Naphthalene and Tetrahydronaphthalene Derivatives", J. Med. Chem., 1991, 34, pp. 3105-3114.

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