Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-06-10
1993-08-10
Dentz, Bernard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514294, 540581, 546 94, A61K 31435, A61K 31395, C07D47118, C07D48718
Patent
active
052349217
ABSTRACT:
The imidazopyridines containing meso-azacycle side chains as described herein find utility as antagonists of the serotonin 5-HT.sub.3 receptor. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT.sub.3 receptors is beneficial. Therapy is indicated for, but not limited to, the treatment of anxiety, psychoses, depression (especially depression accompanied by anxiety), cognitive disorders, substance abuse dependence and/or withdrawal, gastrointestinal motility disturbancies (including esophageal reflux, dyspepsia, irritable bowel syndrome), emesis caused by chemotherapeutic agents, and visceral pain. Additionally, the compounds of the present invention may find utility as enhancers of nasal absorption of bioactive compounds.
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Fludzinski et al. Indazoles as Indole Bioesters J. Med. Chem. 30 No. 9 1535-7 Apr. 1987.
Flynn Daniel L.
Moormann Alan E.
Nosal Roger
Dentz Bernard
G. D. Searle & Co.
Kovacevic Cynthia S.
Matukaitis Paul D.
Williams Roger A.
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