Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Patent
1998-10-29
2000-11-28
Housel, James C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
4242341, 435 732, 530350, A61K 3900, A61K 3902, G01N 33554, C07K 100
Patent
active
061531944
ABSTRACT:
The present invention presents three B. burgdorferi membrane proteins: Oms28, Oms45, and Oms66, each of about 28, 45, and 66 kDa respectively; and with average single channel conductances of about 0.6, 0.22, and 9.7 nS, respectively. Also disclosed are the methods for purifying these proteins from B. burgdorferi, methods for producing antibodies to these proteins, and the resulting antibodies. These proteins and their immunogenic fragments, and antibodies capable of binding to them are useful for inducing an immune response to pathogenic B. burgdorferi as well as providing a diagnostic target for Lyme disease. Further disclosed are the nucleotide and amino acid sequences, the cloning of the genes encoding the proteins and their recombinant proteins, and methods for obtaining the foregoing. Other B. burgdorferi outer membrane spanning proteins (Oms) obtainable by the isolation and purification methods of the present invention.
REFERENCES:
patent: 5470712 (1995-11-01), Simpson et al.
Skare et al. Abstract of the 96th General Meeting of the American Society for Microbiology, May 19-23, 1996. p. 248.
Skare et al. Journal of Clinical Investigation 96:2380-2392, 1995.
Skare et al. Journal of Bacteriology 178(16):4909-4918, 1996.
Norris et al. Injection and Immunity 60(11):4662-4672, 1992.
Blanco David R.
Champion Cheryl I.
Foley Denise M.
Kagan Bruce L.
Lovett Michael A.
Housel James C.
Ryan V.
The Regents of the University of California
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