Process for synthesis of FK-506 C10-C18 intermediates

Details Process for synthesis of FK-506 C10-C18 intermediates Process for synthesis of FK-506 C10-C18 intermediates

1989-03-23

1990-07-10

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

568679, 568680, 568682, C07D26304, C07C 4100, C07C 4112, C07C 4300

Patent

active

049407970

ABSTRACT:
A process is described for the improved synthesis of the optically pure C.sub.10 -C.sub.18 fragment of the macrolide structure of the immunosuppressant FK-506. This compound is also useful as an intermediate for preparing FK-506 derivatives.

REFERENCES:
patent: 4487963 (1984-12-01), Bock et al.
S. Nahm et al., Tetrahedron Lett., 22, No. 39, pp. 3815-3818, 1981.
"Introduction to Organic Chemistry", Streitwieser and Heathcock 1981, 2nd Ed.
"Organic Chemistry", Morrison and Boyd, 1983, 4th Ed.
Evans et al., "Direct Reduction of .beta.-Hydroxy Ketones . . . ", J. Am. Chem. Soc. 110 3560-3578 (1988).

Affiliated with

Also associated with

Rating

Process for synthesis of FK-506 C10-C18 intermediates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for synthesis of FK-506 C10-C18 intermediates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for synthesis of FK-506 C10-C18 intermediates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1721711