Oxindole alkaloids having properties stimulating the immunologic

Details Oxindole alkaloids having properties stimulating the immunologic Oxindole alkaloids having properties stimulating the immunologic

1989-04-03

1990-07-10

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514455, 514456, 514885, A61K 3140, A61K 3135

Patent

active

049407252

ABSTRACT:
Tetra- and pentacyclic oxindole alkaloids, in particular the alloisopteropodine, isomer A, a pentacyclic oxindole alkaloid, are suitable for the unspecific stimulation of the immunologic system, which has been proved by a substantial percental phagocytosis increase in the granulocytic test according to BRANDT (in vitro), a substantial percental increase of the CL-response in the chemiluminescence test (in vitro) and a high increase of the phagocytosis activity of tissue macrophages of the reticoloendothelial system in the carbon-clearence-test (CCT) according to BIOZZI.

REFERENCES:
Chan et al., J. Chem. Soc., C1966(24), 2245-9.
Chem. Abst., Ponglux et al., 87:44172h, 1977.
Chem. Abst., Lleander et al., 83:175457v, 1975.

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