Prostaglandin C.sub.3

Details Prostaglandin C.sub.3 Prostaglandin C.sub.3

1976-01-14

1977-11-15

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

195 30, 2604109R, 260413, 260514D, 424305, 424317, C07C17700

Patent

active

040586642

ABSTRACT:
This invention is a group of prostaglandin-like compounds of the formula: ##STR1## wherein m is 0, 1, 2, or 3 and n is 2, 3, 4, or 5, wherein X and Y are --CH.sub.2 CH.sub.2 -- or X is cis-CH.dbd.CH-- and Y is --CH.sub.2 CH.sub.2 -- or cis--CH.dbd.CH--, and wherein R.sub.1 is hydrogen, alkyl of 1 to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, or phenyl substituted with 1, 2, or 3 chloro or alkyl of 1 to 4 carbon atoms, inclusive, and the pharmacologically acceptable salts thereof when R.sub.1 is hydrogen. These compounds are useful as vasodepressors and antisecretory agents, and in managing cases of renal disfunction.

REFERENCES:
caton, Progress in Medicinal Chemistry, 8, pp. 345-346 (1971).
Vonkeman et al., Biochim. Biophys. Acta 187, 581-583 (1969).
Nakano et al., Eus. J. Biochemistry 11, 386 (1969).

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