Centrally acting 6,7,8,9-tetrahydro-3H-benz(e)indole heterocycli

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514212, 514321, 514322, 514323, 514338, 514364, 514374, 514397, 540480, 540481, 540599, 540603, 546196, 546198, 546199, 546270, 546271, 548131, 548143, 548326, 548238, 5483117, 548427, 548430, C07D20960

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052887480

ABSTRACT:
A compound of Formula I ##STR1## or pharmaceutically acceptable salts of Formula I, where R.sup.1 is H, C.sub.1 -C.sub.3 alkyl, --(CH.sub.2).sub.n CONH.sub.2 where n is 2 to 6, (CH2).sub.n -1-(4,4-dimethylpiperidine-2,6-dione-yl), or cyclopropylmethyl;

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Wikstrom et al. Chem. Abstr vol. 115 entry 23076a abstracts PCT 91-11435 (1991).
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Shagalov, L. B. et al., "Benzindoles. XIV, Synthesis of angular tetrahydro[4,5]- and [6,7]benzindoles," CA 89:146703r for Khim. Geterotsikl. Soedin. 5:634-40 (1978).
Asselin, A. A. et al., "Drug Design via Pharmacophore Identification. Dopaminergic Activity of 3H-Benz[e]indol-8-amines and Their Mode of Interaction with the Dopamine Receptor," J. Med. Chem. 29:648-54 (1986);.
Wikstrom, H. et al., "Resolved 6,7,8,9-Tetrahydro-N,N-dimethyl-3H-benz[e]indol-8-amine: Central Dopamine and Serotonin Receptor Stimulating Properties," J. Med. Chem. 32:2273-76 (1989).
Nichols, D. E. et al., "Synthesis and Evaluation of N,N-Di-n-propyltetrahydrobenz[f]indol-7-amine and Related Congeners as Dopaminergic Agonists," J. Med. Chem. 32:2128-34 (1989).

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