Methods for the use of stabilized fluorocarbon emulsions

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Halogenated hydrocarbon doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514743, 514759, 514832, 514937, A61K 3102

Patent

active

059143525

ABSTRACT:
Storage stable fluorocarbon emulsions having a continuous aqueous phase and a discontinuous fluorocarbon phase, in which the fluorocarbon phase comprises a major amount of a first fluorocarbon or fluorocarbon mixture, and a minor amount of a second fluorocarbon or fluorocarbon mixture, in which the second fluorocarbon has a molecular weight greater than that of the first fluorocarbon and the second fluorocarbon includes a lipophilic moiety in its structure, whereby the second fluorocarbon serves to promote particle size stability in the emulsion while simultaneously providing favorably short organ retention times when administered to animals in vivo.

REFERENCES:
patent: 4289499 (1981-09-01), Clark, Jr. et al.
patent: 4613708 (1986-09-01), Riess et al.
patent: 4859363 (1989-08-01), Davis et al.
patent: 4865836 (1989-09-01), Long, Jr.
patent: 4866096 (1989-09-01), Schweighardt
patent: 4895876 (1990-01-01), Schweighardt et al.
patent: 4927623 (1990-05-01), Long, Jr.
patent: 4987154 (1991-01-01), Long, Jr.
patent: 4993415 (1991-02-01), Long
patent: 5120731 (1992-06-01), Meinert et al.
patent: 5171755 (1992-12-01), Kaufamn et al.
patent: 5264220 (1993-11-01), Long, Jr. et al.
patent: 5393513 (1995-02-01), Long, Jr.
patent: 5441733 (1995-08-01), Meinert
patent: 5567765 (1996-10-01), Moore et al.
patent: 5582813 (1996-12-01), Riess et al.
patent: 5635538 (1997-06-01), Weers et al.
patent: 5674913 (1997-10-01), Clark, Jr.
Reiss et al., "Design Synthesis and Evaluation of Fluorocarbons and Surfactants for In vivo Applications New Perfluoroalkylated Polyhydroxylated Surfactants", Biomat. Artif. Cells Artif. Organs, 16:421-430 (1988).
Kabal'nov, et al., Influence of Nature and Composition of Disperse Phase in Emulsions of Perfluoroorganic Compounds on the Kinetics of the Decrease in Emulsion Dispersity, Killoidn Zh. 48:27-32 (1986).
Riess, Reassessment of criteria for the Selection of Perfluorochemicals for Second-Generation Blood Substitutes: Analysis of Structure/Property Relationships, Artificial Organs 8:44-56 (1984).
Riess, et al., Design, Synthesis and Evaluation of Fluorocarbons and Surfactants for In Vivo Applications New Perfluoroalkylated Polyhydroxylated Surfactants, Biomat. Artif. Cells Artif. Organs 16:421-430 (1988).
Davis, et al., Ostwald Ripening and the Stability of Emulsion Systems: An Explanation for the Effect of an Added Third Component, J. Colloid & Interface Sci., 80:508-511 (1981).
Higuchi, et al., Physical Degradation of Emulsions Via the Molecular Diffusion Route and the Possible Prevention Thereof, J. Pharm. Sci., 51:459-466 (1962).
Kabal'nov, et al., Application of Lifshits-Slezov Theory to Transcondensation of Oil-In-Water Emulsions, Kolloidhyi Z., 46:1108-1111 (1984).
Kabal'nov, et al., Influence of Nature and Composition of Disperse Phase on Stability of Oil-In-Water Emulsions Against Transcondensation, Kolloidnyi Z., 47:1048-1053 (1985).
Lawson, et al., Methods for the Estimation of Vapor Pressures and Oxygen Solubilities of Fluorochemicals for Possible Application in Artificial Blood Formulations, J. Fluorine Chem., 12:221-236 (1978).
Riess, et al., Solubility and Transport Phenomena in Perfluorochemicals Relevant to Blood Substituton and Other Biomedical Applications, Pure & Applied Chem., 54:2383-2406 (1982).
Yamanouchi, et al., Quantitative Structure--In Vivo Half-Life Relationships of Perfluorochemicals for Use as Oxygen Transporters, Cherm. Pharm. Bull., 33:1221-1231 (1985).
Kabal'nov, et al., Ostwald Ripening Theory: Applications to Fluorocarbon Emulsion Stability Adv. Colloid Interface Sci., 38:69-97 (Mar. 23, 1992).
Lifshits, et al., Kinetics of diffusive Decomposition of Supersaturated Solid Solutions Sov. Phys. JEPT, 35:331-339 (1959).
Krafft, et al., Detrimental Effects of Excess Lecithin on the Stability of Fluorocarbon/Lecithin Emulsions J. Phys. Chem., 95:5673-5676 (Jul., 1991).
Lowe, et al., Perfluorochemicals: Blood Substitutes and Beyond Adv. Mater, 3:87-93 (Feb., 1991).
Riess, et al., Fluorocarbon-Based In Vivo Oxygen Transport and Delivery Systems Vox Sang, 61:225-239 (Dec. 1991).
Sharma, et al., Physiochemical Assessment of Novel Formulations of Emulsified Perfluorocarbons Br. J. Pharm., 5p (Date Unknown).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods for the use of stabilized fluorocarbon emulsions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for the use of stabilized fluorocarbon emulsions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for the use of stabilized fluorocarbon emulsions will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1708474

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.