Metal containing polymeric functional microspheres

Details Metal containing polymeric functional microspheres Metal containing polymeric functional microspheres

1977-04-20

1979-06-05

Michl, Paul R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

260 8, 260 296M, 260 4253, 422 68, 1951035R, C08K 310

Patent

active

041573234

ABSTRACT:
Polymeric functional microspheres containing metal or metal compounds are formed by addition polymerization of a covalently bondable olefinic monomer such as hydroxyethylmethacrylate in the presence of finely divided metal or metal oxide particles, such as iron, gold, platinum or magnetite, which are embedded in the resulting microspheres. The microspheres can be covalently bonded to chemotherapeutic agents, antibodies, or other proteins providing a means for labeling or separating labeled cells. Labeled cells or microspheres can be concentrated at a specific body location such as in the vicinity of a malignant tumor by applying a magnetic field to the location and then introducing the magnetically attractable microspheres or cells into the circulatory system of the subject. Labeled cells can be separated from a cell mixture by applying a predetermined magnetic field to a tube in which the mixture is flowing. After collection of the labeled cells, the magnetic field is discontinued and the labeled sub-cell population recovered.

REFERENCES:
patent: 3068185 (1962-12-01), Stamberger
patent: 3183208 (1965-05-01), Jurgeleit
patent: 3519594 (1970-07-01), Michaels
patent: 3544500 (1970-12-01), Osmond
patent: 3884871 (1975-05-01), Herman
patent: 3904568 (1975-09-01), Yamaguchi
patent: 3957741 (1976-05-01), Rembaum
patent: 3971753 (1976-07-01), Frechtling
patent: 4013615 (1977-03-01), Ohashi

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