Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-04-28
1997-03-18
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548453, A01K 3140, C07D48704
Patent
active
056123663
ABSTRACT:
The meso-azacyclic aromatic acid amides and esters of the present invention are useful in the treatment of the central nervous system and gastrointestinal motility disorders such as gastroesophageal reflux, non-ulcer dyspepsia, delayed gastric emptying, ileus, irritable bowel syndrome, and the like. Additionally, the compounds of the present invention find utility as antagonists of serotonin 5-HT.sub.3 receptors. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT.sub.3 receptors is beneficial. Therapy is indicated for, but not limited to, the treatment of anxiety, psychoses, depression (especially depression accompanied by anxiety), cognitive disorders, substance abuse dependence and/or withdrawal, irritable bowel syndrome, emesis caused by chemotherapeutic agents, and visceral pain. Additionally, the compounds of the present invention may find utility as enhancers of nasal absorption of bioactive compounds.
REFERENCES:
patent: 4213983 (1980-07-01), Hadley et al.
patent: 4273778 (1981-06-01), Hadley et al.
patent: 4336259 (1982-06-01), Hadley et al.
patent: 4409225 (1983-10-01), Hadley et al.
patent: 4564624 (1986-01-01), Miyano et al.
patent: 4617401 (1986-10-01), Miyano et al.
patent: 4797387 (1989-01-01), King
patent: 4797406 (1989-01-01), Richardson et al.
patent: 4816453 (1989-03-01), Watts
patent: 4826838 (1989-05-01), Richardson et al.
patent: 5137893 (1992-08-01), Becker et al.
patent: 5140023 (1992-08-01), Becker et al.
patent: 5196547 (1993-03-01), Becker et al.
patent: 5219850 (1993-06-01), Becker et al.
patent: 5227377 (1993-07-01), Flynn et al.
patent: 5234921 (1993-08-01), Flynn et al.
Fludzinski et al. "Indazoles as Indole Biosteres," J. Med. Chem. 30(() 1535-1537 (1987).
Miyano et al. "Synthesis of 7a-Substituted . . . Pyrrolizines . . . " J. Pharm. Sci., vol. 76, No. 5, pp. 416-418 (1987).
Yatani et al. "Effects of New Antiarrhythmic Compound SUN 1165 . . . " Nauyn-Schmiedeberg's Arch. Pharmacol., vol. 326, pp. 163-168 (1984).
Becker Daniel P.
Flynn Daniel L.
Moorman Alan E.
Nosal Roger
Villamil Clara I.
G. D. Searle & Co.
Gerstl Robert
Kovacevic Cynthia S.
Williams Roger A.
LandOfFree
Meso-azacyclic aromatic acid amides and esters as novel serotone does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Meso-azacyclic aromatic acid amides and esters as novel serotone, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Meso-azacyclic aromatic acid amides and esters as novel serotone will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1706663