Synthesis of 3-carbomethoxy-4,5-dimethylthiophene

Details Synthesis of 3-carbomethoxy-4,5-dimethylthiophene Synthesis of 3-carbomethoxy-4,5-dimethylthiophene

1999-09-13

2000-03-14

Lambkin, Deborah C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D33326

Patent

active

060374780

ABSTRACT:
Fungicides having thiophene rings may be made from the intermediate compound 3-carbomethoxy-4,5-dimethylthiophene. That compound, and related compounds, may be produced by reacting an alpha mercaptoketone, e.g., 3-mercapto-2-butanone, with an acrylate, e.g., methyl-3-methoxy acrylate, in the presence of an alkoxide base, e.g., NaOMe, to form the substituted tetrahydrothiophene, followed by conversion to the aromatic thiophene with an acid treatment. The substituted tetrahydrothiophene is a novel compound.

REFERENCES:
patent: 4041047 (1977-08-01), Vlattas
patent: 4689343 (1987-08-01), Gayer et al.
patent: 5034049 (1991-07-01), Kober et al.
patent: 5073184 (1991-12-01), Anthony et al.
patent: 5087288 (1992-02-01), Welter
patent: 5206375 (1993-04-01), Schefczik et al.
patent: 5403939 (1995-04-01), Yazawa et al.
patent: 5486621 (1996-01-01), Phillion et al.
patent: 5498630 (1996-03-01), Phillion et al.
patent: 5679801 (1997-10-01), Caufield et al.
patent: 5747518 (1998-05-01), Yoshikawa et al.
Asinger, Friedrick, et al., "Joint Reaction of Sulfur And Ammonia With Methyl Ethyl Ketone," Liebigs Ann. Chem., Bd. 610, pp. 25-32 (1957).
Coppola, Gary M.,et al., "Synthesis Of Highly Functionalized Thiophenes, 4-Aryl-3-Carboxylate Derivatives," Synlett, p. 1143 (Nov. 1995).
Dubief, Roland, et al., "A Study of .increment.-Thiazolines As Antiradiation Agents," Eur. J. Med. Chem.--Chim. Ther., No. 6, pp. 461-466 (1986).
Hoffmann, Reinhard W., et al., "The Sense Of Asymmetric Induction On Addition To .alpha.-Chiral Aldehydes," Chem. Ber., vol. 118, pp. 3966-3979 (1985).
Chemical Abstract No. 70433h, vol. 71, No. 15 (Oct. 13, 1969).
Chemical Abstract No. 94:103096f, vol. 94, No. 13 (Mar. 30, 1981).

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