Preparation of 3'-substituted-2',3'-dideoxynucleosides and 2'-de

Details Preparation of 3'-substituted-2',3'-dideoxynucleosides and 2'-de Preparation of 3'-substituted-2',3'-dideoxynucleosides and 2'-de

1991-04-05

1995-05-09

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2714, 536 282, C07H 100

Patent

active

054140781

ABSTRACT:
A process for the preparation of 3'-substituted-2',3'-dideoxynucleosides and 2'-deoxynucleosides is provided that utilizes inexpensive, non-carbohydrate, acyclic, achiral starting materials and that proceeds with high enantiomeric and stereochemical control. The method can be used to prepare the pharmaceutically important compounds 3'-azido-3'-deoxythymidine, 3'-azido-2',3'-dideoxyuridine and 3'-fluoro-3'-deoxythymidine.

REFERENCES:
Caron, M., et al., J. Org. Chem. 50, 1557-1560 (1985).
Gao, Y., et al., J. Am. Chem. Soc. 109, 5765-5780 (1987).
Jacobsen, E. N., et al., J. Am. Chem. Soc., vol. 110, No. 6 (1988).
Kwong, H.-L., et al., Tetrahedron Letters, vol. 31, No. 21, 2999-3002 (1990).
Labelle, M., et al., J. Am. Chem. Soc. 110, 4533-4540 (1988).
Marshall J. A., et al., J. Org. Chem., vol. 51, No. 10 (1986).
Maryanoff, B. E., et al., Chem. Rev., 89, 863-927 (1989).
Nagaoka, H., et al., Tetrahedron, vol. 37, No. 23, 3873-3888 (1981).
Vorbruggen, H., et al., Chem. Ber. 114, 1234-1255 (1981).

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