Fluorinated hydroxyalkylquinoline acids as leukotriene antagonis

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546174, 546180, C07D21514, A61K 3147

Patent

active

052703240

ABSTRACT:
Compounds having the formula I: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.

REFERENCES:
patent: 4851409 (1989-07-01), Young et al.
patent: 4920132 (1990-04-01), Huang et al.
patent: 4929626 (1990-05-01), Mohrs et al.
patent: 4962203 (1990-10-01), Young et al.
patent: 4970215 (1990-11-01), Mohrs et al.

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