Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-05-20
1993-12-14
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A01N 4362, A61K 3155
Patent
active
052703061
ABSTRACT:
A method of antagonizing the biological effects of an excitatory amino acid of a subject in need of such antagonization comprising the step of administering to said subject an effective amount of a compound having the formula ##STR1## wherein R.sup.3 is hydrogen, C.sub.1-8 -alkyl which may be branched, or cycloalkylmethyl;
REFERENCES:
De Bonnel et al., Eu J Pharmacology, 93 (1983) 45-54.
Jensen, et al., Life Sciences 33, 393-399 (1983).
Robinson and Coyle, "Glutamate and related acidic excitatory neurotransmitters", FASEB, J., vol. 1, pp. 446-455 (1987).
Krogsgaard-Larsen, "Amino Acid Receptors", Comprehensive Medicinal Chemistry, vol. 3, pp. 493-537, Pergamon Press (1990).
Drejer Jorgen
Jensen Leif H.
Watjen Frank
Cintins Marianne M.
Cook Rebecca
Hueschen Gordon W.
NeuroSearch A/S
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