Process for producing recombinant human serum albumin

Details Process for producing recombinant human serum albumin Process for producing recombinant human serum albumin

1995-05-17

1997-03-18

Chambers, Jasemine C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 691, 530364, C12P 2102, C07K 14765

Patent

active

056121970

ABSTRACT:
A process for producing recombinant human serum albumin is disclosed, which comprises culturing a human serum albumin-producing host, prepared by gene manipulation techniques in a medium that contains an amino acid, preferably at least one amino acid selected from the group consisting of alanine, aspartic acid, glutamic acid, histidine, serine, tryptophan, valine, isoleucine, phenylalanine, cysteine and arginine, more preferably histidine. The process can significantly increase the yield of human serum albumin over that produced by known processes.

REFERENCES:
patent: 5294699 (1994-03-01), Ohmura et al.
patent: 5330901 (1994-07-01), Prevatt et al.
Cook (ed.) "The chemistry and biology of yeasts", Academic Press, New York, N.Y. p. 171 (1958).
Further Studies on the role of phenylalanine in gramicidin S biosynthesis by Bacillus brevis, J-H. David Wu et al., Journal of Biotechnology, pp. 81-94.

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