Mycobacteriophage specific for the mycobacterium tuberculosis co

Details Mycobacteriophage specific for the mycobacterium tuberculosis co Mycobacteriophage specific for the mycobacterium tuberculosis co

1995-03-10

1997-03-18

Housel, James C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

5303881, 5303884, 4242481, C07K 1600, C12Q 168, A61K 3902

Patent

active

056121822

ABSTRACT:
Mycobacteriophage DS6A has been characterized and found to specifically infect all species of the TB complex, without any detectable infection of mycobacteria species other than those of the TB complex. DNA sequence analysis revealed several potential open reading frames, including one encoding a protein analogous to gp37 of mycobacteriophage L5 and a second encoding a protein with significant homology to the S. coelicolor DNA polymerase .beta. subunit. Based on the DNA sequence analysis, cloning sites can be identified for insertion of reporter genes, making DS6A useful as a reporter phage for specific detection and identification of species of the TB complex.

REFERENCES:
Bowman, B. U. 1969 May. Proc Soc. Exp. Biol. Med. 131(1) 196-200.
Sevier, et al. 1981. Clin. Chem. 27(11): 1797-1806.
W. B. Redmond and J. C. Cater "A bacteriophage specific for Mycobacterium tuberculosis, varieties hominis and bovis" Amer. Rev. Resp. Dis. 82:781-786 (1960).
B. U. Bowman "Properties of Mycobacteriophage DS6A I. Immunogenicity in rabbits" PSEBM 131:196-200 (1969).
P. R. J. Gangadharam and C. E. Stager "Loss of acid-fastness of Mycobacterium tuberculosis H37Rv following infection by Mycobacteriophage DS6A" Tubercle 57:203-205 (1976).
L. Sula, et al. "Therapy of experimental tuberculosis in guinea pigs with mycobacterial phages DS-6A, GR-21 T, My-327" Czech. Med. 4:209-214 (1981).
W. R. Jacobs, et al. "Rapid assessment of drug susceptibilities of Mycobacterium tuberculosis by means of luciferase reporter phages" Science 260:819-821 (1993).

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